By Ying Lu, Jiqian Fang, Lu Tian, Hua Jin

ISBN-10: 9810247990

ISBN-13: 9789810247997

ISBN-10: 9810248008

ISBN-13: 9789810248000

ISBN-10: 9812388753

ISBN-13: 9789812388759

This e-book offers new and robust complicated statistical tools which have been utilized in sleek drugs, drug improvement, and epidemiology. a few of these equipment have been in the beginning constructed for tackling clinical difficulties. All 29 chapters are self-contained. every one bankruptcy represents the hot improvement and destiny learn subject matters for a clinical or statistical department. For the advantage of readers with varied statistical history, every one bankruptcy follows an identical sort: the reason of clinical demanding situations, statistical rules and methods, statistical tools and strategies, mathematical comments and history and reference. All chapters are written by way of specialists of the respective subject matters.

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**Extra resources for Advanced Medical Statistics**

**Sample text**

For example, transrectal ultrasound imaging costs $150 to $400 per examination and conventional body coil magnetic resonance imaging (MRI) costs $700 to $1200 per examination. Both MRI and ultrasound could be used to detect advanced stage prostate cancer. 1 have shown that the accuracy of transrectal ultrasound imaging in detecting advanced stage prostate cancer was not statistically different from that of conventional body coil MRI imaging. Thus, choosing ultrasound over MRI could save $300 to $1050 without compromising quality of care.

Wunderlich, C. A. (1871). On the Temperature in Diseases: A Manual of Medical Thermometry, trans. W. Bathurst Woodman. New Sydenham Society, London. 21. Stigler, S. M. (1986). The History of Statistics: The Measurement of Uncertainty before 1900. The Belknap Press of Harvard University Press, Cambridge. 22. Pearson, E. S. (1938). Karl Pearson, Cambridge University Press, London. 23. Pearson, K. (1911). , Macmillan, New York. 24. Cope, Z. (1966). Almroth Wright: Founder of Modern Vaccine-Therapy, Thomas Nelson, London.

Diagnostic results T =1 ··· T =K D=1 z11 ··· zK1 D=0 z10 ··· zK0 Unverified u1 ··· uK Total n1 ··· nK Verified degree of suspicion on the presence of disease for a patient. By postulating a relationship between the observed T and the unobserved T ∗ and a parametric distribution for T ∗ , one can build a parametric model for the ROC curve of a diagnostic test. 30–33 The most commonly used binormal model is proposed by Dorfman and Alf,30 and this model can be summarized in the following result. Result 1: Assume that K − 1 cut-off points, θ1 , .

### Advanced Medical Statistics by Ying Lu, Jiqian Fang, Lu Tian, Hua Jin

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