By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)
This quantity is the court cases of the eleventh foreign convention on Advances in Prostaglandin and Leukotriene study: simple technological know-how and New scientific purposes, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of masking either uncomplicated and medical features of prostaglandin and leukotriene examine.
At this assembly specific emphasis was once given to the aptitude program of the radical COX-2 inhibitors, the genetics of bronchial asthma when it comes to the creation of leukotrienes, and novel mobile networks for the construction of leukotrienes and lipoxins.
Traditionally, as has been performed in previous conferences of this sequence, a large amount of new fabric used to be provided and mentioned this yr, with specific realization given to the latest medical data.
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Extra resources for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications
36 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. Soderstrom M, Bolling A, Hammarstrom S. Induction ofleukotriene C4 synthase activity in differentiating human erythroleukemia cells. Biochem Biophys Res Commun 1992; 189:1043-49. Riddick CA, Serio KJ, Hodulik CR, Ring WL, Regan MS, Bigby TD. TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cellline, THP-1. J Immunol 1999; 162:1101-7. , Petersen J, Austen KF. Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP.
PI A431 RBC PLATELET llBC PBOPs MUTANT -23kD8 .... B A Figure 1. Western blots with two different antibodies against human PHGPx showing the occurrence ofPHGPx in platelets. t of human PHGPx, (B) Monoclonal antibody against human PHGPx. Lysates of A431 cells and recombinant human PHGPx (mutant sec46cys) were used as positive and the lysate of erythrocytes as negative controls. M PI Mk A431 ßACTrN PHGPx 12LOX Figure 2. RT -PCR of mRNAs of PHGPx, 12-LOX and ß-actin in human platelets and megakaryocytes.
Mancini J, Abramovitz M, Cox M, et. al. 5-lipoxygenase-activating protein is an arachidonate binding protein. FEBS Lett 1993;318:277-81. Woods J, Evans J, Ethier D, et. al. 5-Lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 1993;178: 1935-46. Peters-Golden M, McNish R. Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation. Biochem Biophys Res Commun 1993;196:147-53.
Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)