By Saul Suster
The mediastinum is a digital compartment within the chest hollow space that's the seat of a number of important organs and constructions that may be all for quite a few pathologic techniques, together with congenital and developmental abnormalities, inflammatory stipulations, and benign and malignant neoplasms. The Atlas of Mediastinal Pathology presents a pictorial survey of the foremost ailment tactics which can impact this anatomic compartment, together with congenital and purchased cysts, benign hamartomatous tactics, inflammatory techniques regarding the mediastinum, and benign and malignant neoplasms. The latter comprises tumors of the thymus (thymoma and thymic carcinoma), neuroendocrine neoplasms, germ cellphone tumors, mesenchymal neoplasms, and hematolymphoid malignancies. using ancillary diagnostic tools is illustrated, the place applicable, delivering counsel for pathologists in arriving on the right prognosis.
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Additional info for Atlas of Mediastinal Pathology
2 Thymic Epithelial Neoplasms Thymic epithelial neoplasms are the most common primary tumors of the anterior mediastinum. The terminology and classification of these tumors have been a topic of debate for many years and have continued to evolve as we have gained a better understanding of their pathogenesis and biologic behavior. Thymic epithelial neoplasms comprise a spectrum of lesions that can range from very low-grade, well-differentiated tumors to high-grade, poorly differentiated neoplasms, with a wide range of morphologies in-between.
Notice that the nuclear features of the epithelial cells do not differ significantly from those of type B1 thymomas. There can be a range of nuclear features seen in B1 and B2 thymomas, ranging from some cells displaying large vesicular nuclei with no discernible cytoplasm to cells that have slightly smaller nuclei and abundant eosinophilic cytoplasm Fig. 67 High-power magnification of the preceding field in a WHO type B2 thymoma shows abundant thymic epithelial cells, with large vesicular nuclei and prominent eosinophilic nucleoli admixed with the smaller lymphocytes.
68 Another unusual histologic appearance in mixed lymphoepithelial thymoma (WHO type B2) is characterized by sharp segregation between the epithelial cells and the lymphocytes, with the larger epithelial cells crowding around dilated perivascular spaces and the lymphocytes situated in-between; this imparts a distinctly biphasic, compartmentalized appearance 38 2 Thymic Epithelial Neoplasms Fig. 69 Another feature of mixed lymphoepithelial thymoma (WHO type B2) is the presence of dilated perivascular spaces, which can be quite abundant in these tumors.
Atlas of Mediastinal Pathology by Saul Suster